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Friday, July 09, 2010

MooPig Feed for Thought "Genomics Department" :: Numbing NUMBERS

Report by Pat Darnell
UPDATE by PD

3 BILLION
About the number of base pairs in the human genome. The Human Genome Project was launched in 1990 and completed in 2003. The Project cost then about $2,700,000,000 [$2.7 billion] which is about a $-Dollar per Base Pair.

$48,000
San Diego company, Illumina, will sequence your entire genome for you, for this amount.

A new machine on the horizon will be able to do two full sequencings for only $10,000.

The Prize winner is going to be the invention of the machine that will " ... sequence 100 human genomes in 10 days for less that $10,000 each. ... " It's developer will be rewarded a prize of $10 million by the Archon X Prize Foundation.

About that paternity suit, Slick. You might want to just go ahead and pay the child care.

423
Sanger Institute's "Cancer Gene Census" figures there to be this many human genes implicated in cancers.

The WHO, World Health Organization, claims that over 10,000 human diseases may result from a single human gene. YIKES!

3 MILLION
Your FBI has about 8 million individual DNA profiles on record. Individuality is being re-defined ... only one-tenth of one-percent of the entire genome of individuals carries our traits for differences.

This number, 3 million, is the number of base pairs that differ from one person to another, according to our Genome Project.

5,831
As of late in 2009, this is how many genome sequencing projects are registered with GENOMES ONLINE:
  • 4,172 for Bacteria
  • 443 for Fungi
  • 233 for Plants
  • 37 for Primates
  • 84 for other mammals
  • 41 to Fish
  • 8 to Birds
160,000
Smallest known number of base pairs in the bacterium CARSONELLA RUDDI, living symbiotic with insects called PSYLLIDS -- which does not have the genes needed to survive on its own.

133 BILLION
The largest known number of base pairs in the largest genome, belonging to the Marbled Lungfish; Contrasting with only 3 billion base pairs in human sequencing. (discovermagazine. may, 2010)

UPDATE: [source]
Number of species/subspecies available: 4972 (3231 Vertebrates, 1741 Non-Vertebrates)
Smallest animal genome size: 0.02pg, Pratylenchus coffeae, Plant-parasitic nematode
Largest animal genome size: 132.83pg, Protopterus aethiopicus, Marbled lungfish
[NOTEs: Vinogradov (2005) recently argued that the largest genome size among animals is found in the South American lungfish Lepidosiren paradoxa at 80pg, and that Pedersen's (1971) measurement of the marbled lungfish Protopterus was greatly overestimated. However, Vinogradov did not measure P. aethiopicus, he measured P. dolloi. As a result, the largest animal genome reported remains 133pg for P. aethiopicus, followed by the amphibians Necturus lewisi and N. punctatus at 120pg*, followed by the amphibians Necturus maculosus and Amphiuma means and the lungfish Lepidosiren paradoxa (if one accepts Vinogradov's new estimate; three older studies placed it at 113-124pg), all at roughly 80pg.} Got That??
Next WEEK: WHO Knows ??

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