Moo Pig Wisdom is a brilliant combination of Antiquity and Prequel Modern Flea Market. We respectfully ask you to mind your children while here.

Saturday, July 12, 2008

Brain Industries

From Structure to Function: Mapping the Connection Matrix of the Human Brain
Liza Gross

Citation: Gross L (2008) From Structure to Function: Mapping the Connection Matrix of the Human Brain. PLoS Biol 6(7): e164 doi:10.1371/journal.pbio.0060164

Published: July 1, 2008

Copyright: © 2007 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


When American architect Louis Sullivan proffered the enduring mantra of 20th century design—form follows function—he chided his peers for violating in art a law so clearly visible in the “open apple blossom” and “sweeping eagle in his flight.” The notion that the essence of things takes shape in the matter of things, first articulated in Aristotle's philosophy, has long guided biologists' attempts to understand the inner workings of the most complex organ known—the human brain. Fine-grained descriptions of anatomical features of the eye and ear, for example, have yielded critical insights into the neural basis of image and sound perception. But for a systems-level understanding of how the brain works, researchers look to the overall topology of network connections among neurons for answers.

The brain gathers, extracts, and stores salient details about our environment to plan and carry out behaviors that are appropriate (if all goes well) to a given situation. Increasingly, researchers view these perceptual and behavioral responses as computational problems solved by networks made up of more than a hundred billion neurons connected through some hundred trillion synapses. Computational neuroscientists rely on mathematical tools and computer modeling to study how functional groups of neurons interact and how they process, store, and transmit information to mediate human cognition and behavior. Any attempt to understand how a network functions, however, depends on identifying its elements and how they connect to form functional modules. As advances in technology allow researchers to produce clearer pictures of the architecture of neural circuits, new approaches in network analysis and graph theory offer novel insights into how brain networks operate.

In a new study, Patric Hagmann, Olaf Sporns, and their colleagues mapped the large-scale network structure of the nerve fibers linking each region of the human cerebral cortex—the highly furrowed outer surface of the brain responsible for higher cognitive functions. Using structural and functional brain imaging technology, combined with computational analyses, the researchers identified highly connected, centrally located regions of the human cortex. These hubs form a “structural core” of the human brain, which the researchers think may act as central processors, integrating multiple inputs across the cortex. Intriguingly, these hubs correspond to a recently reported “default network,” a neural system that shows increased activity levels when subjects are resting.

Structural and functional brain imaging analyses, combined with computational analyses, reveal highly connected, centrally located regions of the human cortex that form a “structural core” of the brain.

In brains of five healthy human participants, the researchers mapped the network of anatomical connections among the cortex's white matter tracts, the axon fibers that relay messages between neurons, using state-of-the-art diffusion magnetic resonance imaging (MRI) technology. Diffusion MRI is a noninvasive scanning technique that estimates fiber connection trajectories based on gradient maps of the diffusion of water molecules through brain tissue. Recent innovations have yielded a highly sensitive variant of the method, called diffusion spectrum imaging (DSI), which can accurately depict the orientation of multiple fibers that cross a single location. In this paper, the technique is applied for the first time to the whole human cortex.

With the data generated by DSI, the researchers generated a structural connection matrix of the entire brain, divided into 66 cortical anatomical regions and some 1,000 regions of interest (ROIs). They characterized the properties of the global and regional connection matrices using network analysis, based on estimates of elevated node “degree” (fiber counts) and node strength (fiber density), to locate structural hubs across the brain and within local regions. These computational analyses identified several ROIs with a high number of dense connections within subregions of the cortex, ultimately revealing a network core—a set of highly, mutually interconnected nodes—composed of subregions within the parietal and posterior medial cortical regions, including components associated with the “default network” that becomes activated when a person is resting. The fact that these regions span both hemispheres of the brain, the researchers argue, suggests that the structural core may serve as a central integrating system, coordinating processes across segregated regions in both hemispheres.

To investigate the potential role this structural core may serve, the researchers used functional MRI (fMRI) to record brain activity from their five participants, who were asked to rest quietly while remaining alert. The researchers found a significant correlation between the patterns of structural connections estimated by DSI and the functional interactions measured by fMRI among all cortical regions. This correlation indicates that the structure of brain connections shapes the ways in which brain regions interact and exchange signals.

This study represents a major step toward mapping the connectivity patterns of the billions and billions of neurons whose interactions allow us to navigate the daily demands of human existence. The next major challenge will be to incorporate the brain's subcortical regions, such as the thalamus and basal ganglia, into a complete human “connectome” for structurally guided investigations of brain function. Until then, future studies can further explore the relationships between structure and function using the approach described here. And by comparing differences in structural and functional connectivity between individuals, researchers can begin to identify the neural basis of variation in human behavior.

3 comments:

Pribek said...

It's all about the brain isn't it Boss. What destroys us or what brings ecstasy, it's all in the brain.
How much of what ails us is actually neurological? Nobody knows. Immune deficiency is not a weak system, it's an aggressively attacking brain.
Neurologists know some stuff that works but they don't really know why and vice versa. So, figure out the brain and the problems will be solved right?
But, it's not enough to know how and why the brain works, we need to know what it's going to do next. So, once again it's about emergent behavior. It's evolution. But, sometimes the evolution isn't on the money, it takes a few passes.
At some point the AI is ahead of us so, what to do? Do we let the AI figure out how the brain will be evolving and try to eliminate future miscues-head them off? High stakes poker, are we all in?

MooPig said...

Aye, Maty: Pot is right! I ante'd up, partner... we be willin'

Truly, Yes, I am confident that solutions to major difficulties for nerve and respiration systems that support our command centrals' brains will not be found in my lifetime.

A lot of quackery will emerge along the way though.

However, what I'm kind of getting at is that I see the emergence of brain industries.

You know the new aisle at Walgreen's: Brain Hygiene... brain densitometers, coyote urine for the brain stem, vivisection of your brain... the 42 day cycle, Bio rhythms and its maturative stage.

What I am leading up to is in my next found article. see today: McCain's brain is being sized up, with speculation on its ability to deal with diversity without cover up and shady side deals.

hmmmmm... now that's a heavy thought. Ever see that animation TV show Futurama? They have all the heads preserved in jars?

You are being very nice to come and drop in while I am on my cash flow mission from God, [Kingdom Bros/ Blues Bros] almost set up for assembly and production line.
_________________*
I particularly enjoyed this article's writer's attempt at correlating Louis Sullivan to the brain industry as a mantra. Louis is the architect who taught Frank all he knows. Louis had this way of showing up drawing a masterpiece of detailed ornamentations, then leaving it for the apprentices to go drink a few at the tavern.

Louis was the real genius, the Michelangelo-Keefer of the time. FLWright? just a producer.

"Less is More ya knucklehead," I can hear Louis berate little Frank.

Please stay tuned I want to run a series on Brain Ind. Ltd. while I paint up a bunch of linen. Feel free to point to any confusion since I seem to be less focussed in here.

I trust you are feeling perky and sane? pd

Pribek said...

Perky and sane? Neither but not required. Good though, less is more.
Louis Sullivan-I kind of thought that he might be the man; playing chess while everybody else is playing cribbage.

Brain industries or marketing brain products. Well, I do see some memory enhancement products but, I see far more interest in breast and penis enhancement. So, it's an issue of making the brain sexy.

"Take a look at the brain on that one. Like to tap that, eh?"

Considering that 96.864% of all digital technology is used for looking at porn or new ways of playing cowboys and Indians, it seems a stretch.

"What's the ugliest part of your body?
Some say your nose
Some say your toes
(I think it's your mind)
But I think it's YOUR MIND (Your mind)
I think it's your mind, woo woo" yeah, FZ again

I didn't give much thought about the brain, in a real sense, until mine decided to go rogue. Now, I'm interested to no end. Perhaps, the fact that I get to see regularly updated pictures of my own brain, makes me even more interested. But, as you know, I am the anti-demographic. (funny side note, Hoss; as it turns out, according to the pictures, my right temporal lobe never fully developed. I asked the neuro, "How do you account for the fact that the one skill I have been able to develop to any degree, improvisation, is attributed to the right side, Doc?"
"Just more stuff we don't know about")

"You're never going to make any money being the thinking man's anything", is what the wise sage told me.

So, that brings up "cash flow mission from God". One has to be curious about that. But, I know the protocol; "Information will be passed out on a need to know basis."

Best to you and give my love to the Birthday girl.

Blog Archive

SUNDAY :: bishop FM 105.9 Auckland



[Go To SOURCE]

Gary Grainger LIVE BluesShow from Auckland, 6 to 8PM LondonTime .... you listen too.

DISCLAIMER

: It is PROHIBITED by law to use our service or the information it provides to make decisions about consumer credit, employment, insurance, tenant screening, or for any other purpose subject to the Fair Credit Reporting Act, 15 USC 1681 et seq. MooPig Wisdom does not provide consumer reports and is not a consumer reporting agency. The information available on our website may not be 100% accurate, complete, or up to date, so do not use this information as a substitute for your own due diligence, especially if you have concerns about a person’s criminal history. MooPig Wisdom does not make any representation or warranty about the accuracy of the information available through our website or about the character or integrity of the person about whom you inquire. So dip your balls in turpentine and get rid of your own fleas before calling me out.

Ask Someone Who Cares -- SUCH AS SUCH MULCH

To report any abusive, obscene, defamatory, racist,
homophobic or threatening comments, or anything that may violate any applicable laws, please click
--ask_someone_who cares -- ASWC to report with pertinent details.

Anyone posting such material will be immediately mesquitte blackened over a very hot pit fire down at C and J's BBQ on Harvey-Elmo-Weedon Road, and permanently removed from all servers, its IP
owner will be locked in a small room with back issues of
The ECONOMIST, and one scratchy re-mix 8-track tape of Steely Dan's first album...
IP addresses might be recorded to aid us in enforcing these conditions, that is if we cared.

A Fantastically Flawed Script for a Jazz Rock Opera -- "GAZA"

A Fantastically Flawed Script for a Jazz Rock Opera -- "GAZA"
GAZA by Pat Darnell for the Age of Attritionally Challenged

Email MooPigster Customers' Alert

http://www.youtube.com/watch?v=CywR3ouHKP4
If you receive this post via email, you notice it is mostly 'blank'.
We at MooPig Surmise, that at this point, one either says:
"WOW, I'm off the hook, and don't have to pay any attention to that pesky MooPig STUFF!!"
-- OR --
"Hey, where is it ...?"
The answer is: "IT IS A youTUBE presentation"... and you will now click on the http above to go see this modern miracle of technology.

MooPig Wisdom is Your Life-Line to Parody:
24\7 -- We accept all Calls from Contestants

MPW Unique Value Proposition, UVP
Shards of Evidence ... Opinion and Editorial ... We Blunderbuss indigestible Ersatz of Readers' and Writers' ... Explain Strategies of quasi-firms... and some not so quasi ... 110% Proof
One Only
Advertisement Only One
Publisher of Satire ... Enemy to Bombast ... Very Swank ... More Fun to Write than to Read

MooPig Wisdom is online to provide spring board for writers.
MooPig is the Writers' Writer that encourages voice, content, and style. PD

Bill Gaines said it

Bill Gaines said it
"My staff and contributors create the magazine," declared Gaines. "What I create is the atmosphere."